Diogo O Souza Selected Research

Guanosine

1/2021	Effects of intranasal guanosine administration on brain function in a rat model of ischemic stroke.
1/2017	Guanosine Prevents Anhedonic-Like Behavior and Impairment in Hippocampal Glutamate Transport Following Amyloid-β1-40 Administration in Mice.
4/2010	Changes in purines concentration in the cerebrospinal fluid of patients experiencing pain: a case-control study.
2/2010	Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model.
2/2010	Guanosine prevents thermal hyperalgesia in a rat model of peripheral mononeuropathy.
2/2009	The NMDA antagonist MK-801 induces hyperalgesia and increases CSF excitatory amino acids in rats: reversal by guanosine.
10/2008	Antinociceptive effects of intracerebroventricular administration of guanine-based purines in mice: evidences for the mechanism of action.
1/2008	Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines.
4/2005	In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine.
1/2005	Effects of chronic administered guanosine on behavioral parameters and brain glutamate uptake in rats.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Diogo O Souza Research Topics

Disease

12	Seizures (Absence Seizure) 05/2022 - 08/2003
11	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 04/2003
10	Pain (Aches) 01/2022 - 10/2008
8	Ischemia 05/2021 - 06/2002
8	Schizophrenia (Dementia Praecox) 01/2015 - 10/2002
7	Brain Ischemia (Cerebral Ischemia) 05/2021 - 10/2003
7	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2021 - 11/2002
7	Malnutrition (Nutritional Deficiencies) 07/2008 - 06/2002
6	Mania (Manias) 04/2011 - 12/2004
5	Dementia (Dementias) 01/2022 - 01/2003
5	Brain Diseases (Brain Disorder) 01/2021 - 10/2003
5	Brain Injuries (Brain Injury) 01/2016 - 09/2004
5	Body Weight (Weight, Body) 01/2015 - 04/2006
5	Bipolar Disorder (Manic Depressive Psychosis) 04/2011 - 12/2004
4	Memory Disorders (Memory Loss) 05/2022 - 01/2010
4	Chronic Pain 11/2021 - 02/2009
4	Hypoxia (Hypoxemia) 02/2016 - 04/2004
4	Epilepsy (Aura) 08/2011 - 01/2005
3	Cognitive Dysfunction 01/2022 - 01/2007
3	Zika Virus Infection 01/2022 - 07/2019
3	Hyperuricemia 01/2022 - 11/2021
3	Gout 01/2022 - 11/2021
3	Neuroinflammatory Diseases 05/2021 - 11/2015
3	Reperfusion Injury 05/2021 - 10/2014
3	Postoperative Cognitive Complications 11/2020 - 01/2016
3	Parkinson Disease (Parkinson's Disease) 07/2019 - 01/2005
3	Nervous System Diseases (Neurological Disorders) 01/2012 - 09/2002
3	Mental Disorders (Mental Disorder) 03/2011 - 04/2003
3	Psychotic Disorders (Schizoaffective Disorder) 07/2005 - 11/2002
2	Fibromyalgia (Fibrositis) 01/2022 - 11/2021
2	Ischemic Stroke 01/2021 - 07/2003
2	Stroke (Strokes) 01/2021 - 10/2014
2	Mitochondrial Diseases (Mitochondrial Disease) 11/2020 - 11/2010
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 07/2019 - 11/2013
2	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2019 - 01/2011
2	Infarction (Infarctions) 01/2019 - 10/2014
2	Amnesia (Dissociative Amnesia) 10/2011 - 01/2007
2	Acute Pain 04/2010 - 02/2009
2	Hyperalgesia 02/2010 - 02/2009
2	Glutaric Acidemia I 09/2007 - 12/2004

Drug/Important Bio-Agent (IBA)

23	Glutamic Acid (Glutamate)FDA Link 05/2021 - 08/2003
18	Proteins (Proteins, Gene)FDA Link 11/2020 - 06/2002
14	GuanosineIBA 01/2021 - 04/2004
11	PurinesIBA 01/2022 - 04/2004
11	Neuroprotective AgentsIBA 05/2021 - 06/2002
8	Adenosine (Adenocard)FDA LinkGeneric 01/2019 - 10/2002
8	GuanineIBA 02/2016 - 04/2004
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 01/2002
7	Caffeine (No Doz)FDA LinkGeneric 01/2019 - 04/2003
7	Dizocilpine Maleate (Dizocilpine)IBA 02/2010 - 01/2003
7	Quinolinic AcidIBA 01/2008 - 08/2003
6	NucleosidesIBA 01/2021 - 09/2004
5	Amyloid beta-PeptidesIBA 01/2022 - 01/2004
5	Allopurinol (Remid)FDA LinkGeneric 01/2022 - 01/2003
5	Phosphopyruvate Hydratase (Enolase)IBA 11/2020 - 01/2005
5	N-Methylaspartate (NMDA)IBA 02/2009 - 01/2003
5	AcidsIBA 09/2007 - 06/2002
4	EnzymesIBA 01/2022 - 12/2008
4	purineIBA 01/2022 - 01/2017
4	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 10/2003
4	AntioxidantsIBA 05/2018 - 07/2003
4	Adenine FDA LinkGeneric 02/2016 - 10/2008
4	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 01/2015 - 03/2003
4	Pharmaceutical PreparationsIBA 11/2013 - 07/2005
4	Amphetamine (Amfetamine)FDA LinkGeneric 07/2005 - 01/2003
4	ebselenIBA 11/2004 - 09/2002
3	Kainic Acid (Kainate)IBA 05/2022 - 06/2002
3	Xanthine OxidaseIBA 01/2022 - 11/2021
3	Amyloid (Amyloid Fibrils)IBA 11/2020 - 01/2013
3	Purinergic P1 Receptors (Adenosine Receptor)IBA 01/2019 - 01/2012
3	Aspartic Acid (Aspartate)FDA Link 08/2018 - 02/2009
3	Inosine FDA Link 02/2016 - 09/2004
3	Oxygen (Dioxygen)IBA 11/2015 - 10/2003
3	Riluzole FDA LinkGeneric 11/2013 - 01/2003
3	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 01/2013 - 01/2010
3	LithiumIBA 04/2011 - 06/2007
3	Anticonvulsants (Antiepileptic Drugs)IBA 02/2010 - 04/2004
3	Neurotransmitter Agents (Neurotransmitter)IBA 07/2008 - 11/2002
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 05/2022 - 12/2013
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 05/2022 - 09/2003
2	Analgesics (Analgesic Drugs)IBA 01/2022 - 12/2021
2	Biological ProductsIBA 01/2022 - 03/2011
2	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 01/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 05/2018 - 09/2004
2	1,4-dihydropyridine (dihydropyridine)IBA 02/2015 - 10/2014
2	Glutamate Receptors (Glutamate Receptor)IBA 02/2015 - 11/2004
2	Excitatory Amino AcidsIBA 10/2014 - 02/2009
2	Cytochromes c (Cytochrome c)IBA 10/2014 - 10/2014
2	Purinergic P1 Receptor AntagonistsIBA 01/2013 - 01/2007
2	Insulin (Novolin)FDA Link 01/2012 - 10/2011
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 04/2011 - 01/2007
2	MercuryIBA 11/2010 - 10/2006
2	Uric Acid (Urate)IBA 08/2010 - 04/2010
2	Excitatory Amino Acid AgentsIBA 02/2010 - 12/2007
2	Adenosine Diphosphate (ADP)IBA 12/2008 - 09/2004
2	Antipsychotic Agents (Antipsychotics)IBA 08/2008 - 07/2005
2	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2008 - 04/2004

Therapy/Procedure

6	Therapeutics 01/2022 - 06/2007
3	Oral Administration 01/2022 - 10/2014
2	Ligation 05/2015 - 02/2010